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EMF interventions and therapeutic applications in prostate cancer In this perspective, we integrate recent advances through three interconnected axes that bridge biophysical mechanisms with oncological paradigms [Figure 1] and propose a reconciling framework for EMFs duality: (1) Calcium signaling as the central electromagnetic biosensor, where EMFs modulate ion flux to drive tumor aggressiveness or therapeutic vulnerability

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Using the FRET pair TopFluor-PI(4,5)P 2 and TMR-PI(4,5)P 2 , the clustering phenomenon was observed even at low concentrations of PI(4,5)P 2 , and it was determined to be modulated by multivalent metal ions, such as Ca 2+ , Mg 2+ and Al 3+